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American Society of Microbiology ABMM Sample Questions:

1. Which virus is recognized as the leading cause of sporadic, severe gastroenteritis in infants and young children globally, for which effective vaccines are now available?

A) Norovirus
B) Astrovirus
C) Rotavirus
D) Enteric Adenovirus (serotypes 40, 41)


2. A patient with AIDS develops a disseminated fungal infection. Blood cultures grow a yeast that produces pseudohyphae and terminal chlamydospores on cornmeal agar. The patient's CD4+ T-cell count is below 50 cells/µL. The MOST likely causative organism is:

A) Aspergillus fumigatus
B) Candida albicans
C) Cryptococcus neoformans
D) Pneumocystis jirovecii


3. Which serological marker pattern is most consistent with chronic Hepatitis B virus infection with high infectivity?

A) HBsAg (-), Anti-HBs (+), Anti-HBc Total (-), IgM Anti-HBc (-), HBeAg (-), Anti-HBe (-)
B) HBsAg (+), Anti-HBs (-), Anti-HBc Total (+), IgM Anti-HBc (-), HBeAg (+), Anti-HBe (-)
C) HBsAg (-), Anti-HBs (+), Anti-HBc Total (+), IgM Anti-HBc (-), HBeAg (-), Anti-HBe (+)
D) HBsAg (+), Anti-HBs (-), Anti-HBc Total (+), IgM Anti-HBc (+), HBeAg (+), Anti-HBe (-)


4. A clinical microbiology laboratory is using CRISPR-based technology for rapid and sensitive detection of specific bacterial DNA sequences directly from patient samples. This method relies on the ability of the Cas enzyme to:

A) Detect the presence of specific antibodies produced in response to bacterial infection.
B) Amplify target DNA sequences using specific primers and thermal cycling.
C) Reverse transcribe RNA into complementary DNA.
D) Specifically bind to and cleave target DNA sequences guided by a short RNA molecule.


5. An immunocompromised patient develops a disseminated fungal infection. Blood cultures are consistently negative. However, a serum beta-D-glucan assay is markedly elevated. Tissue biopsy reveals the presence of hyaline, septate hyphae with dichotomous branching. The MOST likely causative organism is:

A) Aspergillus fumigatus
B) Mucor species
C) Rhizopus species
D) Cryptococcus neoformans


Solutions:

Question # 1
Answer: C
Question # 2
Answer: B
Question # 3
Answer: B
Question # 4
Answer: D
Question # 5
Answer: A

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