Exam Name: Endocrinology and Diabetes (Specialty Certificate Examination)
Certification Provider: MRCPUK
Corresponding Certification: MRCPUK Certification
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Instant Download MRCPUK : SEND Questions & Answers as PDF & Test Engine
Updated: Sep 29, 2026
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MRCPUK SEND Exam Syllabus Topics:
| Section | Objectives |
|---|---|
| Topic 1: Adrenal Disorders | - Addison disease and adrenal insufficiency - Cushing syndrome |
| Topic 2: Diabetes Mellitus | - Diabetic complications and emergencies - Type 1 and Type 2 diabetes management |
| Topic 3: Thyroid Disease | - Hyperthyroidism and hypothyroidism - Thyroid nodules and cancer |
| Topic 4: Calcium, Bone and Metabolic Disease | - Osteoporosis and metabolic bone disease - Calcium and vitamin D disorders |
| Topic 5: Metabolic Disorders | - Obesity management - Lipid disorders |
| Topic 6: Endocrine Emergencies | - Thyroid and adrenal crisis - Diabetic ketoacidosis and hyperosmolar states |
| Topic 7: Neuroendocrine Tumours and Multiple Endocrine Neoplasia | - Carcinoid and pancreatic NETs - MEN syndromes |
| Topic 8: Pituitary and Hypothalamic Disorders | - Diabetes insipidus and SIADH - Pituitary adenomas and hypopituitarism |
| Topic 9: Reproductive Endocrinology | - Hypogonadism and infertility - Polycystic ovary syndrome (PCOS) |
MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
A 48-year-old woman presented with a 2-year history of weight gain, easy bruising and
mood disturbance.
Investigations:
fasting plasma glucose6.9 mmol/L (3.0-6.0)
low-dose dexamethasone suppression test (2 mg/day for 48 h):
serum cortisol200 nmol/L (<50)
24-h urinary free cortisol (?3)670, 400 and 300 nmol (55-250)
plasma adrenocorticotropic hormone (09.00 h)25.0 pmol/L (3.3-15.4)
MR scan of pituitarynormal
What test is most likely to give a definitive diagnosis?
- A. high-dose dexamethasone suppression text (8 mg/day for 48 h)
- B. CT scan of chest
- C. petrosal sinus sampling
- D. octreotide scan
- E. corticotropin-releasing hormone test
Correct Answer: C 🗳️
A 62-year-old woman with persistent hypertension attended the clinic for review. She had no previous medical history of note and was taking amlodipine, ramipril, bendroflumethiazide, spironolactone and doxazosin. Her blood pressure was raised at 160/100 mmHg.
Investigations:
serum sodium138 mmol/L (137-144)
serum potassium3.8 mmol/L (3.5-4.9)
A blood test for renin and aldosterone concentration was being considered.
For what minimum period should spironolactone be discontinued before this test?
- A. 72 h
- B. 8 weeks
- C. 1 week
- D. 6 weeks
- E. 2 weeks
Correct Answer: D 🗳️
A 67-year-old woman with type 2 diabetes mellitus presented to the foot clinic with an ulcer at the plantar aspect of her fifth left toe. The ulcer probed to bone but there were no signs of inflammation. There had been a little improvement during 6 weeks of podiatric treatment, but there was some concern about possible osteomyelitis. An X-ray of toe 4 weeks previously had been normal.
What is the most appropriate next investigation?
- A. MR scan of foot
- B. plain X-ray of foot
- C. triple phase isotope bone scan
- D. CT scan of foot
- E. white cell labelled scan
Correct Answer: B 🗳️
A 32-year-old man presented to the fertility clinic with his partner. The couple had been together for 4 years and had been trying to conceive for the past 3 years. His partner had children from a previous marriage.
On examination, he was healthy, thin and tall but had bilateral gynaecomastia. His testes felt firm and testicular volumes were 5-6 mL. He had normal pubic and axillary hair.
Investigations:
serum testosterone10.0 nmol/L (9.0-35.0) plasma follicle-stimulating hormone45.0 U/L (1.0-7.0) plasma luteinising hormone32.0 U/L (1.0-10.0)
chromosomal studiesmosaic pattern of 47 XXY/46 XY
semen analysisazoospermia testicular biopsyno viable spermatozoa
What intervention is most likely to lead to conception?
- A. artificial insemination by donor
- B. human chorionic gonadotropin
- C. pulsatile gonadotropin-releasing hormone
- D. testosterone
- E. intracytoplasmic sperm injection
Correct Answer: A 🗳️
A 55-year-old woman presented with thirst, polyuria and polydipsia. Her symptoms had started 9 months previously following a road traffic accident. Her past medical history was normal and she was not taking any regular medication.
On examination, her blood pressure was 130/80 mmHg with no postural drop. Urine volume measured 5 L in 24 hours.
Investigations:
serum sodium131 mmol/L (137-144) serum potassium3.6 mmol/L (3.5-4.9) serum urea2.0 mmol/L (2.5-7.0) serum corrected calcium2.40 mmol/L (2.20-2.60) fasting plasma glucose6.4 mmol/L (3.0-6.0) serum osmolality278 mosmol/kg (278-300) urinary osmolality100 mosmol/kg (100-1000)
What is the most likely diagnosis?
- A. primary polydipsia
- B. syndrome of inappropriate antidiuretic hormone
- C. diabetes mellitus
- D. nephrogenic diabetes insipidus
- E. cranial diabetes insipidus
Correct Answer: A 🗳️
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